Formulating a drug into solid dispersion is an effective approach to enhance the dissolution and bioavailability of poorly soluble drugs. Solvent evaporation using a rotary evaporator is one of the most commonly used methods for laboratory scale preparation of solid dispersions. This work aimed to investigate the influence of different formulation and process variables on the properties of piroxicam (PXM) solid dispersions prepared using rotary evaporator. An 8-factor, 12-run Plackett- Burman design was employed for screening of 8 independent variables namely concentration of drug in the dispersion solution (A), type of carrier (B), type of solvent (C), concentration of carrier (D), concentration of lubricant (E), Stirring time (F), rotation speed during the evaporation process (G) and evaporation temperature (H). Saturation solubility (SS)(Y1) and dissolution efficiency at 15 min (% DE 15 min) (Y2) were selected as response variable (dependent variables). The regression models were significant and exhibited a good description for the responses. Factors A, B, D and H were found to exert significant influence on the solubility and dissolution of PXM from solid dispersions.
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